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Autoimmune autonomic dysfunction syndromes: Potential involvement and pathophysiology related to complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implant–related symptoms and post-COVID syndrome
Mahroum, Naim; Shoenfeld, Yehuda (MDPI (Multidisciplinary Digital Publishing Institute), 2022)The pathophysiological mechanisms involved in chronic disorders such as complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implant–related symptoms, and post-COVID syndrome have not ... -
Autoimmune post-COVID vaccine syndromes: Does the spectrum of autoimmune/inflammatory syndrome expand
Jara, Luis Javier; Vera-Lastra, Olga; Mahroum, Naim; Pineda, Carlos; Shoenfeld, Yehuda (Springer London Ltd, 2022)To date, around 60% of the world population has been protected by vaccines against SARS-CoV-2, significantly reducing the devastating effect of the pandemic and restoring social economic activity through mass vaccination. ... -
Classic pityriasis rosea
Mahroum, Naim; Shoenfeld, Yehuda (NLM (Medline), 2022)P ityriasis rosea is an acute inflammatory skin disorder characterized by papulosquamous skin lesions that appear on the trunk and extremities. The disease affects children and adults, involving slightly more females ... -
Corrigendum to “The mosaic of autoimmunity - A taste for more. The 12th international congress of autoimmunity 2021 (AUTO12) virtual” [Autoimmunity Reviews, Volume 20 (2021) 102945]
Mahroum, Naim; Damoiseaux, Jan; Zoubi, Magdi; Lavine, Noy; Ohayon, Aviran; Amital, Howard; Shoenfeld, Yehuda (Elsevier, 2022)... -
COVID-19 and SLE: Infection and autoimmunity at its best
Mahroum, Naim; Elsalti, Abdulrahman; Özkan, Mehmet Fatih; Shoenfeld, Yehuda (SAGE Publications Ltd, 2023)If one had any doubts before the pandemic regarding the correlation between infections and autoimmunity, COVID-19 left us fascinated on the strong bond between the two entities. The immune and autoimmune reactions seen in ... -
COVID-19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age-associated B cells
Mahroum, Naim; Shoenfeld, Yehuda (Wiley, 2022)The increasing numbers of vaccinated people against COVID-19 worldwide has permitted better visualization and understanding of possible adverse effects, particularly those related to autoimmune phenomena. In this ... -
Ferritin – From iron, through inflammation and autoimmunity, to COVID-19
Mahroum, Naim; Alghory, Amal; Kıyak, Zeynep; Alwani, Abdulkarim; Seida, Ravend; Alrais, Mahmoud; Shoenfeld, Yehuda (Academic Press, 2022)While it took decades to arrive to a conclusion that ferritin is more than an indicator of iron storage level, it took a short period of time through the COVID-19 pandemic to wonder what the reason behind high levels of ... -
Herpes simplex virus and SLE: Though uncommon yet with significant implications
Mahroum, Naim; Elsalti, Abdulrahman; Shoenfeld, Yehuda (NLM (Medline), 2023)To the Editor,The relation between infectious agents, particularly viruses, withautoimmunity and autoimmune diseases, has been extensivelystudied during the last decades. Recently, the association was shownto be even ... -
In response to comment on "Autoimmune post-COVID vaccine syndromes: Does the spectrum of autoimmune/inflammatory syndrome expand?" by Jara LJ et al
Jara, Luis Javier; Vera-Lastra, Olga; Mahroum, Naim; Pineda, Carlos; Shoenfeld, Yehuda (Springer London Ltd, 2022)We thank Dr. Kunal Chandwar for their interest in our article “Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune/infammatory syndrome expand?” Indeed, we have included all of the COVID-19 vaccines, ... -
The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens
Mahroum, Naim; Elsalti, Abdulrahman; Alwani, Abdulkarim; Seida, İsa; Alrais, Mahmoud; Seida, Ravend; Esirgün, Şevval Nil; Abalı, Tunahan; Kıyak, Zeynep; Zoubi, Magdi; Shoenfeld, Yehuda (Elsevier B.V., 2022)While autoimmunity is a branch of medicine linked to every single organ system via direct and indirect pathways, meeting in person to discuss autoimmunity during the 13th international congress on autoimmunity (AUTO13) ... -
The mosaic of autoimmunity-A taste for more. The 12th international congress of autoimmunity 2021 (AUTO12) virtual
Mahroum, Naim; Zoubi, Magdi; Lavine, Noy; Ohayon, Aviran; Amital, Howard; Shoenfeld, Yehuda (Elsevier, 2021)Notwithstanding the fact that the 12th international congress of autoimmunity (AUTO12) was held virtual this year, the number of the abstracts submitted and those presented crossed the thousand marks. Leading investigators ... -
SARS-CoV-2 infection provoking autoimmunity
Mahroum, Naim; Shoenfeld, Yehuda (Oxford University Press, 2023)For decades, infections have been recognized as strong stimulators of the immune system and subsequently serve as a trigger for autoimmunity and autoimmune diseases. While infection is a very broad term, infectious agents ... -
Shared pathogenicity features and sequences between EBV, SARS-CoV-2, and HLA class I molecule-binding motifs with a potential role in autoimmunity
Adıgüzel, Yekbun; Mahroum, Naim; Muller, Sylviane; Blank, Miri; Halpert, Gilad; Shoenfeld, Yehuda (Springer, 2023)Epstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are extraordinary in their ability to activate autoimmunity as well as to induce diverse autoimmune diseases. Here we reviewed the ... -
Systematic review and meta-analysis of tocilizumab therapy versus standard of care in over 15,000 COVID-19 pneumonia patients during the first eight months of the pandemic
Mahroum, Naim; Watad, Abdulla; Bridgewood, Charlie; Mansour, Muhammad; Nasr, Ahmad; Hussein, Amr; Khamisy-Farah, Rola; Farah, Raymond; Gendelman, Omer; Lidar, Merav; Shoenfeld, Yehuda; Amital, Howard; Kong, Jude Dzevela; Wu, Jianhong; Bragazzi, Nicola Luigi; McGonagle, Dennis (MDPI, 2021)Background. Tocilizumab is an anti-IL-6 therapy widely adopted in the management of the so-called "cytokine storm" related to SARS-CoV-2 virus infection, but its effectiveness, use in relation to concomitant corticosteroid ... -
Triggers and regulation: The gut microbiome in rheumatoid arthritis
Mahroum, Naim; Seida, Ravend; Shoenfeld, Yehuda (Taylor and Francis Ltd., 2023)Introduction Rheumatoid arthritis is a chronic inflammatory disease marked by systemic symptoms and joint degeneration. Interestingly, the development and progression of rheumatoid arthritis have been linked to the microbiome, ...